| UROLOGY MAIN SITE | GEN. ADULT UROLOGY | UROLOGIC ONCOLOGY | MALE UROLOGY | TRANSPLANT PROGRAM | |
| PELVIC MEDICINE, INCONTINENCE & RECONST. SURGERY | PEDIATRIC UROLOGY | MIN. INVASIVE SURGERY | |||
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Nestor Fadrique Gonzalez-Cadavid, PhD
a Curriculum Vitae
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| Educational Background | |
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| Undergraduate: | M.Sc. in Biochemistry, University of Buenos Aires, Argentina |
| Medical School: | Ph.D in Biochemistry, University of Buenos Aires, Argentina Ph.D in Biochemistry, University of London, England |
| Board Certifications & Fellowships: |
Research Fellowship, National Council of Scientific Research (Argentina) Research Fellowship (abroad), National Council of Scientific Research Argentina, to work at the Courtauld Institute of Biochemistry, London University, London, England Research Fellowship, Welcome Trust (England), to work at the same institution Senior Research Fellowship, Guggenheim Foundation (USA), to work at the California Institute of Technology, Biology Division, Pasadena, California, USA Short Training Fellowship, International Union Against Cancer, to work at the City of Hope Medical Center, Division of Biology, Duarte, California, USA Eleanor Roosevelt Senior Research Fellowship, International Union Against Cancer, to work at UCLA Medical School, Department of Medicine, Los Angeles, California, USA Senior Research Fellowship, United Nations University, to work at the same institution Public Health Award, to work at the Population Research Center, Torrance, Ca |
| Professional Memberships | |
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| PROFESSIONAL MEMBERSHIP 1966 9. Biochemical Society, Great Britain. 1968 90. Venezuelan Biochemical Society, Venezuela. 1968 90. Venezuelan Association for the Advancement of Science, Venezuela. 1981 8. American Association for the Advancement of Science, USA. 1987 9. Tissue Culture Association, USA. 1989. New York Academy of Sciences, USA.. 1992-on. American Society of Andrology, USA. 1998-on. Endocrine Society, USA 2000-on. Society of Impotence Research (Current: American Society of Sexual Medicine) 2001-on. American Urological Association 2001-on. Society for the Study of Reproduction 2004-on. Society of Sexual Medicine of North America |
| Academic & Medical Staff Appointments | |
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| UNIVERSITY POSITIONS 1968/70. Associate Professor, Department of Biochemistry, School of Science, Central University, Caracas, Venezuela 1970/90. Full Professor, Department of Cell Biology, School of Science, Central University, Caracas, Venezuela. Director, Laboratory of Molecular Oncology. 1990-5. Adjunct Associate Professor of Urology, Department of Urology, UCLA School of Medicine, Los Angeles, CA, USA. Joint with appointment at Harbor-UCLA Research and Education Institute. 1993-on. Director, Urology Research Laboratory, Harbor-UCLA Research and Education Institute, Torrance, CA 1995-on Adjunct Professor of Urology, Department of Urology, UCLA School of Medicine, Los Angeles, CA, USA. Currently, Step II 1997-on. Professor of Medicine, Department of Internal Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, Ca. 2001-on. Director, NIH-RCMI DNA Repository and Molecular Medicine Core, Charles R. Drew University of Medicine and Science, Los Angeles, Ca. Currently, in consideration as NIH-RCMI Molecular Medicine Research Core, sub-contracting LABioMed at Harbor-UCLA. 2004-on. Associate-Director, NIH Program for the Biological Effects of Androgens in Men and Women. Charles R. Drew University/UCLA. Charles R. Drew University of Medicine and Science, Los Angeles, Ca VISITING FACULTY POSITIONS 1971. Visiting Scientist, Massachusetts Institute of Technology, Division of Biology, Cambridge, Massachusetts, USA 1978-9. Gosney Visiting Associate in Biology, California Institute of Technology, Biology Division, Pasadena, California, USA 1980-1. Visiting Associate in Biology, same institution 1982. Visiting Professor, University of Buenos Aires, Argentina, School of Biochemistry, Buenos Aires, Argentina 1987/88. Visiting Professor, UCLA School of Medicine, Division of Hematology & Oncology, Los Angeles, CA, USA 1988-9. Visiting Scientist, UCLA School of Medicine, Division of Urology, Los Angeles, California, USA |
| Research & Clinical Interests | |
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| Principal Investigator. NIH/NIDDK R01. Nitric Oxide Synthase in Aging Principal Investigator. American Diabetes Association. Erectile Dysfunction and Vascular Fibrosis in Diabetes Principal Investigator. Department of Defense. Pharmacological Prevention and Reversion of Erectile Dysfunction after Radical Prostatectomy by Modulation of Nitric Oxide/cGMP Pathways Principal Investigator. Department of Defense. Modulation of Stem cell Differentiation and Myostatin as an Approach to Counteract Fibrosis in Dystrophic Muscle Regeneration after Injury Principal Investigador. Takeda Pharmaceuticals. Antifibrotic and Renoprotective Effects of Pioglitazone on Type 2 Diabetes Related Tubulo Interstitial Fibrosis Principal Investigator LABioMed. Characterization of Stem Cells from Human Skeletal Muscle for the Therapy of Congestive Heart Disease Principal Investigator LABioMed. Reversión of Levator Ani Atrophy by Muscle Derived Stem Cells in a Rat Model of Stress Urinary Incontinence Principal Investigator. NIH/NIDDK R21. Cell selective Expression of Fibrotic gene Pathways Core Director. NIH RCMI DNA Molecular Medicine and Stem Cells Core. Associate Director. NIH/NICHD. Androgen Center Grant |
| Awards & Honors | |
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| Gold Medal to the top graduate, University of Buenos Aires Gold Medal to the best Ph.D. thesis, University of Buenos Aires Harbor-UCLA, Research and Education Institute, award to scientific research by institutional PhDs |
| Personal | |
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| Languages Spoken: | Spanish (native) and French (reading) |
Additional Information |
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ADDITIONAL INFORMATION
Selected peer-reviewed publications from 2003-2007 (from a list of 153 (Dec 07) on CV). Also three patents issued and one under review. List available on request
Ferrini MG, Magee TR, Vernet D, Rajfer J, Gonzalez-Cadavid NF (2003) Penile neuronal nitric oxide synthase (PnNOS) and its regulatory proteins are present in hypothalamic and spinal cord regions involved in the control of penile erection. J Compar Neurol 458:46-61
Magee T, Zeller CB, Ferrini M, Davila H, Vernet D, Burnett AL, Rajfer J, González-Cadavid NF (2003) A protein inhibitor of NOS (PIN) is expressed in the rat and mouse penile nerves and co-localizes with penile neuronal NOS (PnNOS) Biol Reprod 68:478-488.
Berman JR, Almeida FG, Jolin J, Raz S, Chaudhuri G, Gonzalez-Cadavid NF (2003) Androgen receptors, aromatase, and 5--reductase in human vagina: correlation with menopausal status. Fertil Steril, 79:925-931.
Davila H, Ferrini M, Rajfer J, Gonzalez-Cadavid NF (2003) Fibrin induction of a Peyronie's-like plaque in the rat penile tunica albuginea. A new model for Peyronie's disease. Br J Urol, 91:830-838.
Reisz-Porszasz S, Bhasin S, Artaza JN, Shen R, Sinha-Hikim I, Houge A, Gonzalez-Cadavid NF (2003) Reduction of skeletal muscle mass in a transgenic mouse that hyperexpresses myostatin in the muscle. Am J Physiol, Am J Physiol, 2003 Oct;285(4):E876-888.
Ma K, Mallidis C, Bhasin S, Mahabadi V, Artaza J, Gonzalez-Cadavid N, Arias J, Salehian B (2003) Glucocorticoid-Induced Skeletal Muscle Atrophy is Associated with Upregulation of Myostatin Gene Expression. Am J Physiol, 285:E363-371.
Valente EG, Vernet D, Ferrini MG, Qian A, Rajfer J, Gonzalez-Cadavid NF (2003) PDE L-arginine and PDE inhibitors counteract fibrosis in Peyronie’s plaque and related fibroblast cultures. Nitric Oxide, 9:229-244.
Singh R, Artaza JN, Taylor WE, (
Liu W, Thomas SG, Asa SL, Gonzalez-Cadavid NF, Bhasin S, Ezzat S (2003) Myostatin is a Skeletal Muscle Target of Growth Hormone Anabolic Action. J Clin Endocrin Metabol, 88:5490-5496
Bhasin S, Taylor W, Singh R, Artaza J, Sinha-hickim I, Jasuja R, Choi H, Gonzalez-Cadavid NF (2003) The mechanisms of androgen effects on body composition: mesenchymal pluripotent cell as the target of androgen action. J Gerontol, 58:M1103-10.
Ferrini MG, Davila H, Valente EG, (
Qian A, Meals R, Rajfer J,
Davila HH, Magee TR, Rajfer J, Gonzalez-Cadavid NF (2004) Gene therapy with the inducible nitric oxide synthase (iNOS) cDNA regresses the fibrotic plaque in an animal model of Peyronie’s disease. Biol Reprod, 71:1568-1577
Davila HH, Rajfer J,
Sinha-Hikim I, Taylor WE, Gonzalez-Cadavid NF, Zheng W, Bhasin S (2004) Androgen receptor in human skeletal muscle and cultured muscle satellite cells: Up-regulation by androgen treatment. J Clin Endocr Metabol 89:5245-5255.
Davila H, Magee TR, Rajfer J,
Hikim AP, Vera Y, Vernet D, Castanares M, Diaz-Romero M, Ferrini M, Swerdloff RS, Gonzalez-Cadavid NF, Wang C (2005) Involvement of nitric oxide-mediated intrinsic pathway signaling in age-related increase in germ cell apoptosis in male brown-norway rats. J Gerontol A Biol Sci Med Sci 60:702-708.
Artaza JN, Bhasin S, Magee TR, Reisz-Porszasz S, Shen R, Groome NP, Fareez MM, Gonzalez-Cadavid NF (2005) Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T(1/2) mesenchymal multipotent cells. Endocrinology 146:3547-3557.
Vernet D, Qian A, Nolazco G, Cantini L, Magee TR, Ferrini MG, Rajfer J, Gonzalez-Cadavid NF (2005) Evidence that osteogenic progenitor cells in the human tunica albuginea may originate from stem cells. Implications for Peyronie’s disease. Biol Reprod, 73:1199-1210.
Jasuja R, Ramaraj P, Mac RP, Singh AB, Storer TW, Artaza J, Miller A, Singh R, Taylor WE, Lee ML, Davidson T, Sinha-Hikim I, Gonzalez-Cadavid N, Bhasin S (2005) Delta-4-androstene-3,17-dione binds androgen receptor, promotes myogenesis in vitro, and increases serum testosterone levels, fat-free mass, and muscle strength in hypogonadal men. J Clin Endocrinol Metab. 90:855-863.
Gonzalez-Cadavid NF, Rajfer J (2005) The pleiotropic effects of inducible nitric oxide synthase on the
physiology and pathology of penile erection. Curr Pharm Des 11:4041-4046
Saenz de Tejada I, Angulo J, Cellek S, Gonzalez-Cadavid N, Heaton J, Pickard R, Simonsen U (2005) Physiology of erectile function. J Sex Med 1:254-265.
Saenz de Tejada I, Angulo J, Cellek S, Gonzalez-Cadavid N, Heaton J, Pickard R, Simonsen U (2005) Pathophysiology of erectile dysfunction. J Sex Med 2:26-39.
Ferrini MG, Nolazco G, Vernet D, Gonzalez-Cadavid NF*, Berman J* (*: equal contributors) (2006) Increased vaginal oxidative stress, apoptosis, and inducible nitric oxide synthase in a diabetic rat model: implications for vaginal fibrosis. Fertil Steril, 86:1152-1163.
Ferrini MG, Kovanecz I, Nolazco G, Rajfer J, Gonzalez-Cadavid NF (2006) Effects of long-term treatment with vardenafil on the development of the fibrotic plaque in a rat model of Peyronie’s disease BJU Int, 97:625-633
Singh R, Artaza JN, Taylor WE, Braga M, Yuan X, Gonzalez-Cadavid NF, Bhasin S (2006) Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors. Endocrinology. 2006 Jan;147(1):141-54.
Vernet D, Magee TR, Qian A, Rajfer J, Gonzalez-Cadavid NF (2006) Long-term continuous incubation with high doses of tadalafil does not up-regulate the levels of phosphodiesterase 5 (pde5) in cultures of human penile smooth muscle cells. J Sex Med 3:84-94; discussion 94-95
Magee TR, Artaza JN, Ferrini MG, Zuniga FI, Cantini L, Reisz-Porszasz S, Rajfer J, Gonzalez-Cadavid NF (2006). Myostatin shRNA gene therapy increases muscle mass. J Gene Med 8:1171-81
Kovanecz I, Ferrini MG, Vernet D, Nolazco G, Rajfer J, Gonzalez-Cadavid NF (2006). Pioglitazone prevents corporal veno-occlusive dysfunction (CVOD) in a rat model of type 2 diabetes melittus. BJU Int, 98:116-124
Ferrini MG, Davila H, Kovanecz I, Sanchez S, Gonzalez-Cadavid NF* Rajfer J* (*: equal contributors) (2006) Long-term continuous treatment with vardenafil prevents fibrosis and preserves smooth muscle content in the rat corpora cavernosa after bilateral cavernosal nerve transection. Urology, 2006 Aug;68(2):429-35.
Ferrini MG, Kovanecz I, Sanchez S, Vernet D, Davila HH, Rajfer J, Gonzalez-Cadavid NF (2007) ,Long-term continuous treatment with sildenafil ameliorates aging-related erectile dysfunction and the underlying corporal fibrosis. Biol Reprod, 76:915-923
Artaza JN, Reisz-Porszasz S, Dow JS, Kloner RA, Tsao J, Bhasin S, Gonzalez-Cadavid NF (2007) Alterations in myostatin expression are associated with changes in cardiac left ventricular mass but not ejection fraction in the mouse. J Endocrinol, 194(1):63-76.
Gonzalez-Cadavid NF, Rajfer J (2007) Experimental models for the study of the cellular and molecular pathophysiology of Peyronie’s disease. In: Current Clinical Urology: Peyronie’s Disease, A Guide to Clinical Management, ed by L.A. Levine, Humana Press,
Magee TR, Kovanecz I, Davila HH, Ferrini MG, Cantini L, Vernet D, Zuniga FI, Rajfer J, Gonzalez-Cadavid NF (2007) Antisense and short hairpin RNA (shRNA) constructs targeting PIN (protein inhibitor of NOS) ameliorate aging-related erectile dysfunction in the rat. J Sex Medic, 4(3):633-43.
Kovanecz I, Ferrini MG, Davila HH, Rajfer J, Gonzalez-Cadavid NF (2007) Pioglitazone ameliorates penile corpora veno-occlusive dysfunction (CVOD) in the aged rat. BJU Intn, BJU Int. 2007 Oct;100(4):867-74.
Kovanecz I, Rambhatla A, Ferrini MG, Vernet D, Sanchez S, Rajfer J, Gonzalez-Cadavid NF (2007) Long term sildenafil treatment ameliorates corporal veno-occlusive dysfunction (CVOD) induced by cavernosal nerve resection in rats. Int J Impot Res, 2007, 100(4):867-74..
Kovanecz I, Rambhatla A, Ferrini MG, Vernet D, Sanchez S, Rajfer J, Gonzalez-Cadavid NF (2007) Chronic daily tadalafil prevents the corporal fibrosis and veno-occlusive dysfunction (CVOD) that occurs following cavernosal nerve resection in the rat. BJU Int. 2007 Sep 20; [Epub ahead of print].
Rambhatla A, Kovanecz I, Ferrini M, Gonzalez-Cadavid NF, Rajfer J.Rationale for phosphodiesterase 5 inhibitor use post-radical prostatectomy: experimental and clinical review. Int J Impot Res. 2007 Aug 2; [Epub ahead of print]
Nolazco G, Kovanecz I, Vernet D, Ferrini M, Gelfand B, Tsao J, Magee T, Rajfer J, Gonzalez-Cadavid NF (2007) Effect of muscle derived stem cells on the restoration of corpora cavernosa smooth muscle and erectile function in the aged rat. BJU Int, in press
Artaza JN, Singh R, Ferrini MG, Braga M, Tsao J, Gonzalez-Cadavid NF (2007) Myostatin promotes a fibrotic phenotypic switch in multipotent C3h 10T1/2 cells without affecting their differentiation into myofibroblasts. J Endocrinol, in press
ACADEMIC ACTIVITIES AND COMMITTEES
1970 71. Member of the Organizing Committee of the 10th Congress of Latin American Society of Physiological Sciences (ALALC).
1970 71. Member of the Organizing Committee of the 1st Congress of Pan American
Association of Biochemical Societies (PAABS).
1973 75. Chairman of the Committee on Scientific Research, School of Biology, Central University of Venezuela.
1978. Member and main writer/editor of the Committee that prepared the text of a bill on the scientific investigator career in Venezuela, Venezuelan National Council of Scientific Research, CONICIT.
1977 78. Chairman of the Organizing Committee of the 2nd PAABS Congress.
1976 78. Member of Executive Council of the Venezuela Biochemical Society.
1978 79. Secretary General of the Pan American Association of Biochemical Societies,
1979 80. Chairman of the Biology Grants Committee, CONICIT.
1979 85. Member of the Symposium Committee of the International Union of Biochemistry.
1981. Advisor to CONICIT on genetic engineering applications to biotechnology
1981. Advisor to CONICIT on the cooperation agreements with the US National Academy of Sciences.
1982 84. Vice Chairman of the Committee on Genetic Engineering, CONICIT.
1974 78. Coordinator of the Research Group on Molecular Biology, School of Biology, Central University of Venezuela.
1985 87. Member of Technical Council, Center of Cell Biology, Central University of Venezuela.
1985 86. Member of Post graduate Committee on Cell Biology, Central University of Venezuela.
1985 89. Member of National Committee on Genetic Engineering and Biotechnology, appointed by the President of Venezuela.
1985. Scientific Consultant, Lopapa Institute Project.'Institute of Molecular Oncology.' .
1985 86. Member of the Committee on Retirements and Pension Plans of the National Council of Universities, and that of the Central University of Venezuela.
1986. Organizer of the Colombian/Venezuelan Meeting on Binational Biotechnology Projects, Cucuta, Colombia.
1986. CONICIT representative to the Biotechnology Committee of SELA (Economic System of Latin America).
1989. Scientific Advisor to the Director of UNESCO on US molecular biology/genetic engineering institutions.
1993-on. Recombinant DNA Committee, Research and Education Institute, Harbor-UCLA Center
1998/9. Panel member. First International Consultation on Erectile Dysfunction. World Health Organization/International Union Against Cancer. Amsterdam, Dallas, Paris
1997. Career investigator (not-activated), National Council of Scientific and Technological Research (CONICET), Buenos Aires, Argentina.
1998-on. Ad hoc evaluator, National Fund of Science and technology (FONCYT), National Agency of Scientific and Technologic Promotion, Buenos Aires, Argentina
2001-on. Director, RCMI DNA Repository and Molecular Medicine Core, Charles C. Drew University, Los Angeles, CA
2001-on. Ad hoc consultant/lecturer: Merck, AMGEN, and several small corporations.
2002-on. Member of Search Committee for Research Director, Female Sexual Medicine Center,: UCLA School of Medicine, Department of Urology
2003. Panel member. Second International Consultation on Erectile Dysfunction. World Health Organization/International Union Against Cancer. Amsterdam, Dallas, Paris
2006. Scientific Advisory Committee, Charles R Drew University
2007. Faculty appointments committee, Charles R Drew University
AD HOC REVIEWER
Journals: Endocrinology, Nature Medicine, American Journal of Physiology, Biology of Reproduction, Journal of Andrology, Journal of Urology, Urology, Nitric Oxide, Cancer; Journal of Endocrinology, Experimental Gerontology, Asian Journal of Andrology; Journal of Sexual Medicine; Endocrinology; Circulation Research, and others
NIH: NIDDK, NIH (1995). Center Program Grants on Prostate Growth
NIDDK, NIH (2001) Diabetes Research and Training Center
Welcome Trust, England (2002)
Department of Defense (2004), Skeletal muscle biology and pathology
Singapore University, Faculty appointments
Editorial Board member, Journal of Sexual Medicine
SCIENTIFIC PRESENTATIONS
Invited speaker and presenter in multiple scientific meetings in the USA and overseas, recently mainly for the Americal Urological Association, Endocrine Society, Society of Sexual Medicine, and others. List of 180 titles available on request
