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Department of
Urology Intranet

Jacob Rajfer, MD

a Curriculum Vitae

Jacob Rajfer, MD
Professor of Urology
Chief of Urology, Harbor-UCLA Medical Center


Phone: 310-206-8164
Educational Background
Undergraduate: B.S., University of Illinois, Chicago, Illinois
Medical School: M.D., Northwestern University, Chicago, Illinois
Residency: Internship, LA County-USC Medical Center, Los Angeles, California
Resident in Surgery, St. Josephs Hospital, Denver, Colorado,
Senior Assistant Resident in Urology, The Johns Hopkins Hospital, Baltimore, Maryland
Chief Resident in Urology, The Johns Hopkins Hospital, Baltimore, Maryland
Board
Certifications
& Fellowships:
Research Fellow in Urology, The Johns Hopkins University School of Medicine, Baltimore, Maryland
Board Certified, American Board of Urology

Specialties
Male infertility, sexual dysfunction, prostate disease

Professional Memberships
American Fertility Society
Kidney Foundation of Southern California
Society for the Study of Reproduction
Los Angeles Urological Society
Southern California Transplant Society
Society of University Urologists
Pacific Coast Fertility Society
Western Section, American Urological Association, Inc.
UCLA Jonsson Comprehensive Cancer Center
American College of Surgeons - Fellow
American Urological Association
American Society of Andrology
Urologic Society for Transplantation and Vascular Surgery
California Urological Society
Western Association of Transplant Surgeons
The Endocrine Society
American Society of Transplant Surgeons
Society for the Study of Impotence
Society of Pediatric Urology
Western Urologic Forum
American Academy of Pediatric

Academic & Medical Staff Appointments
1978-80 Assistant Professor, Department of Urology, University of Washington, Seattle, Washington
1980-83 Assistant Professor, Division of Urology, Department of Surgery,
University of California at Los Angeles, Los Angeles, California
1983-89 Associate Professor, Division of Urology, Department of Surgery, University of California at Los Angeles, Los Angeles, California
1989-present Professor, Division of Urology, Department of Surgery,
University of California at Los Angeles, Los Angeles, California

Research & Clinical Interests
Dr. Rajfer has made UCLA one of the top basic science research centers in the field of impotence. It was these research activities that led to the discovery at UCLA of what chemicals cause an erection and explained in detail how drugs like Viagra work in helping men with impotence.

During Dr. Rajfer's tenure as Chief of Urology at Harbor-UCLA Medical Center, many clinical aspects of Urology including pediatrics, renal transplantation, oncology and andrology have been expanded and a number of important discoveries have been made.

Awards & Honors
1977 3rd Prize, Laboratory Research, Grayson Carroll Essay,
American Urological Association, Chicago, Illinois
1978 1st Prize, Laboratory Research, Grayson Carroll Essay, American Urological Association, Chicago, Illinois
1983 2nd Prize, Joseph F. McCarthy Essay, Western Section, American Urological Association, Vancouver, B.C.
1984 1st Prize, Joseph F. McCarthy Essay, Western Section, American Urological Association, Reno, NV.
1985 1st Prize, Joseph F. McCarthy Essay, Western Section, American Urological Association, Anaheim, CA
1986 Honorable Mention, Research Prize, Section on Urology, American Academy of Pediatrics, Washington, D.C.
1992-01 Best Doctors in America
1995 President, Los Angeles Urological Society
1996 Certificate of Achievement Award, AUA, Orlando, Fl.
1996 Honorary Fellowship, American Academy of Pediatrics
2001 America’s Top Doctors

Personal
Philosophy of Care: I believe you need to pay attention to your patient. I like to develop a personal rapport. When you demonstrate concern, your patient will relate to you, and you to the patient.
Why I entered Medicine: I had not yet picked which specialty I wanted to go into, until I met a very charismatic professor who was a urologist. I'm sure that teacher inspired many other medical students to select urology.


  Additional Information


PATENTS

 

1.   AMELIORATION OF HUMAN ERECTILE DYSFUNCTION BY TREATMENT WITH iNOS, INDUCERS OF iNOS OR iNOS cDNA.  January 14, l997.

 

2.  NMDA  RECEPTOR  BLOCKERS  IN  THE  THERAPY  OF  UROGENITAL  DISEASE  April 21, 2000. 

 

 

BOOK REVIEWS

 

1.         "Traumatic injuries of the Genitourinary System" by McDougal & Persky.  Critical Care     

             Medicine. 9:562, 1981.

 

2.         "Percutaneous Renal Surgery" by Wickham and Miller.  N. Eng. J. Med. 310: 1062,        

             1984.

 

3.         "Prostate Cancer" by Wm. J. Catalona. N. Engl. J. Med. 312:1201, 1985.

 

4.         "Contemporary Management of Impotence and Infertility" by Tanagho, Lue, and                

 

5.         "Impotence: diagnosis and management of male erectile dysfunction" by Kirby

 

Selected Bibliography:

                  

 

1          von Keitz A, Rajfer J, Segal S, Murphy A, Denne J, Costigan T, Lockhart D, Beasley CM Jr and Emmick JT.  A multicenter, randomized, double-blind, crossover study to evaluate patient preference between tadalafil and sildenafil.  Eur Urol 45:499-507, 2004.  

 

2.           Ferrini MG, Davila HH, Valente EA, Gonzalez-Cadavid NF and Rajfer J.  Aging-related induction of inducible nitric oxide synthase is vasculo-protective to the arterial media. Cardiovasc. Res, 61:796-805, 2004.

 

3.           Carson CC, Rajfer J, Eardley I, Carrier S, Denne JS, Walker DJ, Shen W and Cordell WH. The efficacy and safety of tadalafil: an update.  BJU Int. 93:1276-1281, 2004.

 

4.            Jalkut M, Gonzalez-Cadavid N and Rajfer J.  New discoveries in the basic science understanding of Peyronie’s disease.  Curr Urol Rep 5:478-84, 2004.

 

5.            Qian A, Meals RA, Rajfer J and Gonzalez-Cadavid NF.  Comparison of gene expression profiles between Peyronie’s disease and Dupuytren’s contracture.  Urology 64:399-404, 2004. 

 

6.            Rajfer J.  Endothelial dysfunction as a cause of erectile dysfunction – misdiagnosis or misnomer?  Urology 64:193-4, 2004.

 

7.            Davila HH, Magee TR, Vernet D, Rajfer J and Gonzalez-Cadavid NF. Gene transfer of inducible nitric oxide synthase complementary DNA regresses the fibrotic plaque in an animal model of Peyronie’s disease.  Biol Reprod 71:1568-77, 2004.

 

8.      Gonzalez-Cadavid NF and Rajfer J.  Therapy of erectile dysfunction: potential future treatments.  Endocrine 23:167-76, 2004.

 

9.      Gonzalez-Cadavid, NF and Rajfer J.  Molecular pathophysiology and gene therapy of aging-related erectile dysfunction.  Exp. Gerontology 39:1705-1712, 2004.

 

10.      Davila, HH, Rajfer J and Gonzalez-Cadavid NF.  Corporal veno-occlusive dysfunction in aging rats: evaluation by cavernosometry and cavernosography.  Urology 64:1261, 2004.

 

11.      Gore JL, Swerdloff RS and Rajfer J.  Androgen deficiency in the etiology and treatment of erectile dysfunction.  Urol Clin North Am  32:457-468, 2005.

 

12.      Singer JS, Ettenger RB, Gore JL, Gritsch A, Rajfer J, Rosenthal JT, Schulam P.  Laparoscopic versus open renal procurement for pediatric recipients of living donor renal transplantation. Am J Transplant  5:2514-20, 2005.

 

13.      Vernet D, Nolazco-Gomez G, Cantini L, Magee TR, Qian A, Rajfer J and Gonzalez-Cadavid.  Evidence that osteogenic progenitor cells in the human tunica albuginea may originate from stem cells: implications for Peyronie’s disease.  Biol Reprod 73:1199-1210, 2005.

 

14.      Davila HH, Magee TR, Zuniga F, Rajfer J and Gonzalez-Cadavid NF.  Peyronie’s disease is associated with an increase in plasminogen activator inhibitor (PAI-1) in the fibrotic plaque.  Urology 65:645-8, 2005.

 

15.      Gonzalez-Cadavid NF and Rajfer J.  Mechanisms of disease: new insights into the cellular and molecular pathology of Peyronie’s disease.  Nat Clin Pract Urol 2:291-7, 2005.

 

16.      Rajfer J, Gore J, Kaufman J and Gonzalez-Cadavid NF.  Case report: avoidance of palpable corporal fibrosis due to priapism with upregulators of nitric oxide.  J Sex Med., 3:173-6, 2006.

 

17.      Vernet D, Magee TR, Qian A, Rajfer J and Gonzalez-Cadavid NF.  Phosphodiesterase type 5 is not upregulated by tadalafil in cultures of human penile cells.  J Sex Med 3:84-95, 2006.

 

18.      Ferrini MF, Kovanecz I, Nolazco G, Rajfer J and Gonzalez-Cadavid NF.  Effects of long-term treatment with vardenafil on the development of the fibrotic plaque in a rat model of Peyronie’s disease.   Brit J Urol 97:625-33, 2006.

 

19.      Kovanecz I, Ferrini MG, VernetD, Nolazco G, Rajfer J and Gonzalez-Cadavid NF.  Piaglitazone prevents corporal veno-occlusive dysfunction in a rat model of type 2 diabetes mellitus.  Brit J Urol 98:116-24, 2006.

 

20.      Magee TR, Artaza JN, Ferrini MF, Vernet D, Zuniga FI, Cantini L, Reisz-Prrszasz S, Rajfer J and Gonzalez-Cadavid NF.  Myostatin short interfering hairpin RNA gene transfer increases skeletal muscle mass.  J Gene Med 8:1171-81, 2006

 

21.      Rajfer J.  Is TESA passe?  J. Androl, 27:491, 2006.

 

22.      Shabsigh R, Rajfer J, Aversa A, Traish AM, Yassin A, Kalinchenko SY and Buvat J.  The evolving role of testosterone in the treatment of erectile dysfunction. Int J Clin Pract 60:1087-1092, 2006.

 

23.      Ferrini MF, Davila HH, Kovanecz I, Sanchez S, Gonzalez-Cadavid NF and Rajfer J.  Vardenafil prevents the fibrosis and loss of corporal smooth muscle following bilateral cavernosal nerve resection in the rat.  Urology 68:429-435, 2006.

 

24.      Rajfer J, Aliotta PJ, Steidle CP, Fitch WP, Zhao Y and Yu A.  Tadalafil dosed once a day in men with erectile dysfunction: a randomized, double-blind, placebo controlled study in the United States.  Intl J Imp Res 19:95-103, 2007.