| UROLOGY MAIN SITE | GEN. ADULT UROLOGY | UROLOGIC ONCOLOGY | MALE UROLOGY | TRANSPLANT PROGRAM | |
| PELVIC MEDICINE, INCONTINENCE & RECONST. SURGERY | PEDIATRIC UROLOGY | MIN. INVASIVE SURGERY | |||
|
Jonathan Said, MD
a Curriculum Vitae
|
|
|||||||||||||||||||||||
| Educational Background | |
|
|
|
| Medical School: | M.D. University of Witwatersrand Medical School, Johannesburg, 1965-1971 South Africa |
| Residency: | Intern in Medicine and Surgery at Johannesburg General Hospital, Johannesburg, South Africa 1972 Junior Assistant Resident in Pathology at the Mallory Institute of Pathology, Boston, MA 1973 Senior Assistant Resident in Pathology at Peter Bent Brigham Hospital, Boston, MA 1974 |
| Board Certifications & Fellowships: |
Clinical Fellow, Harvard Medical School 1974, 1975 Fellow in Hematopathology, Peter Bent Brigham Hospital 1976 Research Fellow in Pathology, Harvard Medical School 1976 |
| Specialties | |
|
|
|
| Pathology |
| Professional Memberships | |
|
|
|
| International Academy of Pathology, United States-Canadian Division 1977- American Association of Pathologists 1982- American Society of Hematology 1982- Society for Hematopathology 1982- Los Angeles County Pathology Society 1982- Histochemical Society 1985- Society for Ultrastructural Pathology 1990- College of American Pathologists 1992- Association of Directors of Anatomic and Surgical Pathology1996- Clinical Immunology Society 1999- |
| Academic & Medical Staff Appointments | |
|
|
|
| Professor of Pathology and Urology David Geffen School of Medicine at UCLA Chief Division of Anatomic Pathology UCLA Department of Pathology and Laboratory Medicine Chief Division of Surgical Pathology UCLA Department of Pathology and Laboratory Medicine Co-Director Tissue Procurement Core Laboratory (TPCL) UCLA Pathology Department and Jonsson Comprehensive Cancer Center Specialist Consultant Olive View Medical Center Associate director Hematopathology Fellowship Training Program Associate Pathologist, Peter Bent Brigham Hospital Instructor in Pathology, Harvard Medical School Assistant Professor of Pathology, Harvard Medical School Associate Pathologist, Cedars-Sinai Medical Center, Los Angeles, Director Immunopathology Electron Microscopy Cedar-Sinai Medical Center |
| Awards & Honors | |
|
|
|
| Listed in "Best Doctors in America", Woodward and White 2004-2006 Journal front cover Journal of Pathology Vol. 182 No. 3, July 1997. Journal front cover Applied Immunohistochemistry Vol. 11 No 3, September 2003. Elected Fellow of the International Society of Urologic Pathology for ‘significant contribution to the advancement of urologic pathology’ |
Additional Information |
|
|
|
|
Bibliography (since 2003)
1. Nador, R.G., Chadburn, A., Sulur, G., Cesarman, E., Said, J.W.,Knowles,D.M.:
AIDS-related Polymorphic lymphoproliferative disorders. Am J Surg Pathol 27:293-
302, 2003.
2. De Vos, S., Krug, U., Hofmann, W-K, Pinkus, G.S., Swerdlow, S.H.,
Wachsman, W., Grogan, T., Yue, C., Koeffler, H.P., Said J.: Gene expression
profiling in laser microdissected normal follicular mantles, mantle cell lymphoma, and
blastoid variant of mantle cell lymphoma. Diagnostic Molec. Pathol. 12: 35-43,
2003.
3. DeVos S, Hofmann W, Grogan T, Miller T, Koeffler HP, Said J. Genes
differentially expressed in serial samples of transformed follicular lymphomas Lab
Invest 83:271-285, 2003.
4. Zisman, A., Wieder, J., Pantuck, A., Chao, D., Dorey, F., Said, J., Gitlitz, B.,
Figlin, R., Belldegrun, A.: Renal cell carcinoma with tumor thrombus extension:
Biology, role of nephrectomy and response to immunotherapy. J Urol 169:906-919,
2003.
5. Vegesna V, O’Kelly J, Said J, Uskovic M, Binderup L, Koeffler HP: Ability of potent
vitamin D3 analogs to inhibit growth of prostate cancer cells in vivo. Anticancer Res
23: 283-289, 2003
6. Roberts AA, Amano M, Felten C, Galvan M, Sulur G, Pinter-Brown L, Dobbeling U,
Burg G, Said J, Baum LG: Galectin-1 mediated apoptosis in mycosis fungoides: The
role of CD7 and cell surface glycosylation. Modern Pathol 16:543-551, 2003.
7. Allan J. Pantuck, Amnon Zisman, Fredrick Dorey, Debby H. Chao, Ken-ryu Han,
Jonathan Said, Barbara J. Gitlitz, Robert A. Figlin and Arie S. Belldegrun: Renal Cell
Carcinoma with Retroperitoneal Lymph Nodes: Role of Lymph Node Dissection.
Journal of Urology (169: 2076-2083, 2003).
8. Pantuck A, Zisman A, Dorey F, Chao D, Han K, Said J, Gitlitz B, Belldegrun A,
Figlin R: Renal Cell Carcinoma with Retroperitoneal Lymph Nodes: Impact on Survival
and Benefits of Immunotherapy. Cancer 97:2995-3002, 2003.
9. Palapattu GS, Pantuck AJ, Dorey F, Said JW, Figlin RA: Collecting system
invasion in renal cell carcinoma: impact on prognosis and future staging strategies. J
Urol 170:768-772, 2003.
10. Tanosaki S, Ikezoe T, Heaney A, Said JW, Dan K, Akashi M, Koeffler HP: Effect
of ligands of nuclear hormone receptors on sodium/iodide symporter expression and
activity in breast cancer cells. Breast Cancer Res Treat 79:335-345, 2003.
11. Kumagai T, O’Kelly J, Said JW, Koeffler H: Non-Calcemic vitamin D2 analog, 19-
nor-1,25(OH)2D2: Antitumor activities against leukemia, Myeloma and Colon
Cancer. Journal of the National Cancer Institute 95:896-905, 2003.
12. Said J: Genetic and molecular genetic studies in the diagnosis of immune-related
lymphoproliferative disorders. Human Pathology 34:341-345, 2003.
13. Zisman A, Pantuck AJ, Bui MH, Said JW, Caliliw RR, Rao N, Shintaku P, Berger
F, Gambhir SS, Belldegrun AS: LABAZ1: A metastatic tumor model for renal cell
carcinoma expressing the carbonic anhydrase type 9 tumor antigen. Cancer
Research 63: 4952-4959,2003.
14. Said J.: Transformation to aggressive B-cell lymphoma: morphology,
immunophenotype, and molecular characteristics. Appl Immunohistochem Mol
Morphol 11(3):199-205, 2003.
15. Schiller G, Said J, Pal S: Hairy cell leukemia and sarcoidosis: a case report and
review of the literature. Leukemia 17:2057-2059, 2003.
16. Han K, Bleumer I, Pantuck AJ, Kim F, Dorey J, Janzen N, Zisman A, Dinney CP,
Wood CG, Swanson DA, Said JW, Figlin R, Mulders FA, Belldegrun AS: Validation
of an integrated staging system toward improved prognostication of patients with
localized renal cell carcinoma in an international population. J Urol 170:2221-2224,
2003.
17. Takai, N., Desmond, J. C. Kumagai, T. Gui, D. Said, J. W. Whittaker, S.
Miyakawa, Koeffler, H. P. Histone deacetylase inhibitors have a profound antigrowth
activity in endometrial cancer cells. Clin Cancer Res 10:1141-1149, 2004.
18. Han K R, Seligson DN, Liu X, Horvath S, Shintaku IP, Thomas GV, Said JW,
Reiter RE: Prostate stem cell antigen (PSC A) expression is associated with
Gleason score, seminal vesicle invasion, and capsular invasion in prostate cancer. J
Urol 171, 1117-1121, 2004.
19. Tsukasaki K, Tanosaki S, DeVos S, Hofmann WK, Gombart AF, Krebs J,
Jauch A, Betram CR, Nagai K, Tomonaga M, Said JW, Koeffler, H. P. Identifying
progression-associated genes in adult T-cell leukemia/lymphoma by using
oligonucleotide microarrays. Int J Cancer 109:875-881, 2004.
20. Xie D, Yin D, Tong X, O-Kelly J, Mori A, Miller C, Black K, Gui D, Said JW,
Koeffler, H. P. Cyr61 is overexpressed in gliomas and involved in integrin-linked
kinase-mediated Akt and beta-catenin-TCF/Lef signaling pathways. Cancer Research
64: 1987-1996, 2004.
21. Hoyer KK, Panag M, Gui D, Shintaku IP, Kuwabara I, Lui FT, Said JW, Baum
LG, Teitell, M. A. An anti-apoptotic role for galectin-3 in diffuse large B-cell
lymphomas. Am J Pathol 864: 893-902, 2004
22. Kumagai T, Ikezoe T, Gui D, O'Kelly J, Tong XJ, Cohen FJ, Said JW, Koeffler, H.
P. RWJ-241947 (MCC-555), a unique peroxisome proliferator-activated receptor-
gamma ligand with antitumor activity against human prostate cancer in vitro and in
beige/nude/ X-linked immunodeficient mice and enhancement of apoptosis in
myeloma cells induced by arsenic trioxide. Clinical Cancer Research 10:1508-1520,
2004.
23. Takeuchi S, De Vos S, Fermin AC, Grogan TM, Seo H, Said JW, Koeffler, H. P.
Allelic loss during progression of follicular lymphoma. Leuk Res 28:567-569, 2004.
24. Jin YP, Fishbein MC, Said JW, Jindra PT, Rajalingham R, Rozengurt E, Reed, E.
F. Anti-HLA class I antibody-mediated activation of the PI3K/Akt signaling pathway
and induction of Bcl-2 and Bcl-xL expression in endothelial cells. Hum Immunol
65:291-302, 2004.
25. Kumagai T, Ikezoe T, Gui D, O'Kelly J, Tong XJ, Coen FJ, Said JW, Koeffler, H.
P. RWJ-241947 (MCC-555), a unique peroxisome proliferator-activated receptor-
gamma ligand with antitumor activity against human prostate cancer in vitro and in
beige/nude/ X-linked immunodeficient mice and enhancement of apoptosis in
myeloma cells induced by arsenic trioxide. Clin Cancer Res 10:1508-1520, 2004.
26. Garraway IP, Seligson D, Said J, Horvath S: Trefoil factor 3 is overexpressed in
human prostate cancer. Prostate 61:209, 2004.
27. Kawabata H, Fleming RE, Gui D, Moon SY, Saitoh T, O'Kelley J, Umehara Y,
Wano Y, Said JW, Koeffler HP. Expression of hepcidin is down-regulated in TfR2
mutant mice manifesting a phenotype of hereditary hemochromatosis. Blood 2004.
28. Han K, Janzen NK, McWhorter V, Kim HL, Pantuck AJ, Zisman A, Figlin RA,
Said JW, Belldegrun AS: Cystic renal cell carcinoma: biology and clinical behaviour.
Urologic Oncology 22:410-414, 2004
29. Chien W, Kumagai T, Miller CW, Desmond JC, Frank JM, Said JW, Koeffler
HP. Cyr61 suppresses growth of human endometrial cancer cells. J Biol Chem 51:
53087-96, 2004.
30.Loya AG, Said JW, Grant, EG. Epidermoid cyst of the testis, radiologic
pathologic correlation. Radiographics 24: 243-246, 2004
31. Chadburn A, Hyjek E, Mathew S, Cesarman E, Said J, Knowles DM. KSHV-
positive solid lymphomas represent an extra-cavitary variant of primary effusion
lymphoma. Am J. Surg Pathol 28:1401-1416, 2004
32.Takai N, Kawamata N, Gui D, Said JW, Miyakawa I, Koeffler, H. P. Human
ovarian carcinoma cells: Histone deacetylase inhibitors exhibit antiproliferative activity
and potently induce apoptosis. Cancer 101: 2760-2770, 2004
33. Ikezoe T, Hisatake Y, Takeuchi T, Ohtsuki Y, Yang Y, Said JW, Taguchi H,
Koeffler, H. P. HIV-1 protease inhibitor, ritonavir: a potent inhibitor of CYP3A4,
enhanced the anticancer effects of docetaxel in androgen-independent prostate
cancer cells in vitro and in vivo. Cancer Research 20:7426-7431, 2004
34. Chih DY, Park DJ, Gross M, Idos G, Vuong PT, Hirama T, Chumakov AM, Said
J, Koeffler HP. Protein partners of EBP/epsilon. Exp Hematol 32:1173-1181, 2004.
35. Thomas GV, Horvath S, Smith BL, Crosby K, Schrage M, Said J, DeKernion J,
Reiter RE, Sawyers CL: Antibody based profiling of the phosphoinositide 3-kinase
pathway in clinical prostate cancer. Clin Cancer Res 10:8351-8356, 2004.
36. Sakajiri S, Kumagai T, Kawamata N, Saitoh T, Said JW, Koeffler, HP: Histone
deacetylase inhibitors profoundly decrease proliferation of human lymphoid cancer
cell lines. Exp Hematol 33:53-61, 2005.
37. Kim, G, S. Rajasekaran, G. Thomas, E. Rosen, E. Landaw, P. Shintaku, C.
Lassman, J. Said, and A K. Rajasekaran: Renal clear-cell carcinoma: an
ultrastructural study on the junctional complexes. Histology and Histopathology 20,
35-44, 2005.
38. Kawabata H, Fleming RE, Gui D, Moon SY, Saitoh T, O'Kelly J, Umehara Y,
Wano Y, Said JW, Koeffler, HP: Expression of hepcidin is down-regulated in TfR2
mutant mice manifesting a phenotype of hereditary hemochromatosis. Blood 105:
376-381, 2005.
39. Wu H, Said JW, Ames ED, Chen C, McWhorter V, Chen P, Ghali V, Pinkus GS:
First reported cases of Intravascular Large Cell Lymphoma of NK cell type. Am J
