| UROLOGY MAIN SITE | GEN. ADULT UROLOGY | UROLOGIC ONCOLOGY | MALE UROLOGY | TRANSPLANT PROGRAM | |
| PELVIC MEDICINE, INCONTINENCE & RECONST. SURGERY | PEDIATRIC UROLOGY | MIN. INVASIVE SURGERY | |||
|
Eric Vilain, MD, PhD
a Curriculum Vitae
|
|
||||||||||||||||||||
| Educational Background | |
|
|
|
| Undergraduate: | Universite Pierre et Marie Curie (Paris 6) (College, Bachelor of Science) |
| Medical School: | Faculte de Medecine Necker Enfants Malades, Paris (Medical School) Universite Pierre et Marie Curie / Pasteur Institute (Ph.D) |
| Residency: | 1989-1990 Resident, Pediatrics. Paris Hospital System. 1990-1993 Graduate Work on Genetics of Sex Determination in Humans, (Dr. Marc Fellous, M.D., Advisor) Pasteur Institute, Paris, France. 1993-1994 Military service at Paris Military Hospital (Val-de-Grace), Cytogenetics Unit 1994-1996 Resident, Pediatrics, Pediatric Endocrinology and Pediatric Genetics, Paris Hospital System. 1996-1998 Resident and Fellow, Medical Genetics, Department of Pediatrics, UCLA School of Medicine. |
| Professional Memberships | |
|
|
|
| American College of Medical Genetics- Fellow American Medical Association American Society for Human Genetics Endocrine Society Lawson Wilkins Pediatric Endocrinology Society Society for Inherited Metabolic Disorders Society for Pediatric Research International Academy of Sex Research—Fellow |
| Academic & Medical Staff Appointments | |
|
|
|
| Principal Investigator, Human Genetics Laboratory, UCLA Chief, Division of Medical Genetics, UCLA Director, Laboratory of Sexual Medicine, Urology, UCLA Associate Professor, Department of Human Genetics, UCLA Associate Professor, Department of Pediatrics, UCLA Associate Professor, Department of Urology, UCLA Faculty Member, ACCESS Graduate Program in Biomedical Sciences Faculty Member, Intercampus Medical Genetics Training Program Faculty Member, Neuroscience Inter Departmental Program Attending Physician, Outpatient Medical Genetics Clinic, UCLA School of Medicine Attending Physician, Inpatient Medical Genetics Consultation Service Graduate Advisor, Department of Human Genetics, UCLA Member, Mental Retardation Research Center, UCLA Fellow, Center for Society and Genetics, UCL |
| Research & Clinical Interests | |
|
|
|
| Sexual Development and Gender-based medicine |
| Awards & Honors | |
|
|
|
| 1995 Award, French section of the International Academy of Pathology 1996 David Smith Award, Western Society for Pediatric Research 2002 Basil O'Connor Award, March of Dimes |
Additional Information |
|
|
|
|
1. Domenice S, Correa RV, Costa EM, Nishi MY, Vilain E, Arnhold IJ, Mendonca BB. Mutations in the SRY, DAX1, SF1 and WNT4 genes in Brazilian sex-reversed patients. Braz J Med Biol Res, 37(1):145-50, 2004.
2. Keegan CE, Vilain E, Mohammed M, Lehoczky J, Dobyns WB, Archer SM, Innis JW. Microcephaly jejunal atresia, aberrant right bronchus, ocular anomalies, and XY sex reversal. Am. J. Med. Genet., 125A(3):293-8, 2004.
3. Fleming, A. & Vilain, E. The endless quest for sex determination genes. Clin Genet 67:15-25, 2004.
4. Jack GS, Nikolova G, Vilain E, Raz S, Rodriguez LV. Familial transmission of genitovaginal prolapse. Int. Urogynecol J Pelvic Floor Dysfunct. 2005.
5. Bocklandt S, Horvath S, Vilain E, Hamer DH. Extreme skewing of X inactivation in mothers of homosexual men. Human Genetics, 118(6):691-4, 2006.
6. Bernard P, Ludbrook L, Queipo G, Dinulos MB, Kletter GB, Zhang YH, Phelan JK, McCabe ER, Harley VB, Vilain E. A familial missense mutation in the hinge region of DAX1 associated with late onset AHC in a prepubertal female. Mol. Genet. Metab. In press.
7. Dewing P, Chiang C, Sinchak K, Sim H, Chesselet MF, Micevych P, Harley V, Vilain E. Direct role of Sry of mammalian brain function. Current Biology, 16(4):415-20, 2006.
8. Hutz JE, Krause AS, Achermann JC, Vilain E, Tauber M, Lecointre C, McCabe ER, Hammer GD, Keegan CE. IMAGe association and congenital adrenal hypoplasia: No disease-causing mutations found in the ACD gene. Mol Genet. Metab., 88:272-279, 2006.
9. Lacombe A, Lelievre V, Roselli CE, Salameh W, Lawson G, Muller JM, Waschek J, Vilain E. Protection against testicular aging in PACAP null mice. Proc. Natl. Acad. Sci. USA, 103(10): 3793-3798, 2006.
10. Hughes IA, Houk C, Ahmed SF, Lee PA; LWPES Consensus Group; ESPE Consensus Group.Consensus statement on management of intersex disorders. Arch Dis Child. 2006 Jul;91(7):554-63.
11. Lacombe A, Lee H, Zahed L, Choucair M, Muller J, Nelson SF, Salameh W, Vilain E. Disruption of POF1B binding to non-muscle actin filaments causes premature ovarian failure. Am. J. Hum. Genet., 79:113-119, 2006.
12. Nikolova G, Berkovitz S, Sinsheimer J, Rodriguez L, Vilain E (co-last author). Sequence variant in the laminin gamma1 (LAMC1) gene associated with familial pelvic organ prolapse. Human Genetics, 2006, 120(6):847-56.
13. Bernard P, Fleming A, Lacombe A, Vilain E. Wnt4 inhibits the canonical Wnt pathway and increases cell-cell adhesion by redirecting b-catenin to the cell membrane. In revision at Mol. Cell. Biol.
14. Nikolova G, Sincheimer J, Eicher E, Vilain E. Region on mouse chromosome 11 provides protection from sex reversal in a C57/BL6J-YPos congenic strain. Submitted to PNAS.
15.Lacombe A, Lelievre V, Roselli C, Muller JM, Waschek J, Vilain E. Lack of Vasoactive Intestinal Peptide reduces steroidogenesis and aging in mouse testis. In revision at Journal of Endocrinology.
