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Department of
Urology Intranet

Lily Wu, MD, PhD
a Curriculum Vitae

Lily Wu, MD, PhD
Associate Professor of Urology

Phone: 310-794-4390
Educational Background
Undergraduate: B.A., University of California, Berkeley, California
Medical School: M.D., University of California, Los Angeles, California
Ph.D., University of California, Los Angeles, California
Residency: Pediatrics, University of California, Los Angeles, California
Board
Certifications
& Fellowships:		 Pediatrics, Hematology and Oncology, University of California, Los Angeles, California

Research & Clinical Interests
Molecular biology, gene therapy, adenovirus, prostate cancer

Awards & Honors
1983-1989 Medical Scientist Training Program, UCLA
1994-1997 Howard Hughes Medical Institute Postdoctoral Fellowship for Physicians


  Additional Information


Publications (Since 2002)

  1. Adams JY, Sato M, Johnson M, Berger F, Gambhir S S, Carey M, Iruela-Arispe ML, Wu L. Visualization of Advanced Human Prostate Cancer Lesions in Living Mice by a Targeted Gene Transfer Vector and Optical Imaging. Nat Med 2002 8:891 - 897.
  2. Inubushi M, Wu JC, Gambhir SS, Sundaresan G, Satyamurthy N, Namavari M, Yee S, Barrio JR, Stout D, Chatziioannou AF, Wu L, Schelbert HR. Positron-emission tomography reporter gene expression imaging in rat myocardium. Circulation 2003 107:326-32.
  3. Zhang L, Johnson M, Sato M, Ilagan R, Le K, Iyer M, Gambhir SS, Wu L and Carey M. Imaging the Dynamic Androgen Receptor Signaling During Cancer Progression. Can Res 2003 63:4552-60.
  4. Sato M, Johnson M, Zhang L, Zhang B, Le K, Gambhir SS, Carey M and Wu L. Optimization of Adenoviral Vectors to Direct Highly Amplified Prostate-Specific Gene Expression for Imaging and Gene Therapy. Mol Ther 2003 8:726-737.
  5. Wu L, Johnson M, and Sato M. Transcriptionally-targeted Gene Therapy to Detect and Treat Cancer. Trends in Molecular Medicine, 2003 9:421-429.
  6. Sato M, and Wu L. Integrated, Molecular Engineering Approaches to Develop Prostate Cancer Gene Therapy. Current Gene Therapy, 2003 3:452-467.
  7. Ray S, Paulmurugan R, Hildebrandt I, Iyer M, Wu L, Carey M, Gambhir SS. Novel bidirectional vector strategy for amplification of therapeutic and reporter gene expression. Hu Gene Ther. 2004 15:681-90.
  8. Iyer M, Salazar FB, Lewis X, Zhang L, Carey M, Wu L, Gambhir SS. Noninvasive Imaging Of Enhanced Prostate-Specific Gene Expression Using A Two-Step Transcriptional Amplification-Based Lentivirus Vector. Mol Ther. 2004 10:545-52.
  9. Tsui K, Wu L, Chang P, Hsieh M, Juang H. Identifying The Combination Of The Transcriptional Regulatory Sequences On Prostate Specific Antigen And Human Glandular Kallikrein Genes J Urol. 2004 172:2029-34.
  10. Iyer M, Salazar FB, Lewis X, Zhang L, Wu L, Carey M, Gambhir SS. Noninvasive Imaging Of A Transgenic Mouse Model Using A Prostate-Specific Two-Step Transcriptional Amplification Strategy. Transgenic Res, 2005, 14:47-55.
  11. Morizono K, Xie Y, Ringpis G, Johnson M, Nassanian H, Lee B, Wu L, Chen ISY. Lentiviral Vector Retargeting To P-Glycoprotein On Metastatic Melanoma Via Intravenous Injection. Nat Med 2005, 11:346-52.
  12. Sato M, Johnson M, Zhang L, Gambhir SS, Carey M, Wu L. Functionality of Androgen Receptor-based Gene Expression Imaging in Hormone Refractory Prostate Cancer. Clin Can Res 2005, 11:3743-9.
  13. Bao Y, Peng W, Verbitsky A, Chen J, Wu L, Rauen KA, Sawicki JA. Human coxsackie adenovirus receptor (CAR) expression in transgenic mouse prostate tumors enhances adenoviral delivery of genes. Prostate 2005, 64:401-7.
  14. Johnson M, Sato M, Burton J, Gambhir SS, Carey M, Wu L. MicroPET/CT monitoring of herpes thymidine kinase suicide gene therapy in a prostate cancer xenograft: the advantage of a cell-specific transcriptional targeting approach. 2005 Mol Imaging, 4:463-72.
  15. Bjorndahl MA, Cao R, Burton JB, Brakenhielm E, Religa P, Galter D, Wu L, Cao Y. Vascular Endothelial Growth Factor A Promotes Tumoral Lymphangiogenesis and Lymphatic Metastasis. 2005 Can Res, 65:9261-8.
  16. Ilagan R, Zhang L, Pottratz J, Le K, Salas S, Iyer M, Wu L, Gambhir SS, Carey M. Imaging Androgen Receptor Function During Anti-Androgen Treatment In Prostate Cancer Xenografts. 2005 Mol Can Ther, 4:1662-9.
  17. Iyer M, Sato M, Johnson M, Gambhir SS, Wu L. Applications of Molecular Imaging in Cancer Gene Therapy. 2005 Curr Gene Ther, 5:607-18.
  18. Iyer M, Salazar FB, Wu L, Carey M, Gambhir SS. Bioluminescence Imaging of Systemic Tumor Targeting Using a Prostate-Specific Lentiviral Vector. Hum Gene Ther. 2006, 17:125-32.
  19. Wang Y, Iyer M, Annala A, Wu L, Carey M, Gambhir SS. Noninvasive indirect imaging of vascular endothelial growth factor gene expression using bioluminescence imaging in living transgenic mice. Physiol Genomics. 2006 24:173-80.
  20. Figueiredo ML, Sato M, Johnson M, Wu L. Specific Targeting of Gene Therapy to Prostate Cancer Using a Two-step Transcriptional Amplification System. Future Oncology, 2006 2;391-406.
  21. Lee NV, Sato M, Annis D, Loo J, Wu L, Mosher D, Iruela-Arispe ML. Processing of thrombospondin 1 and 2 by ADAMTS1 releases anti-angiogenic fragments. EMBO J, 2006 25:5270-83.
  22. Ilagan R, Pottratz J, Le K, Zhang L Wong SG, Ayala R, Iyer M, Wu L, Gambhir SS, Carey M. Imaging Mitogen-activated Protein Kinase Function In Xenograft Models of Prostate Cancer. Can Res, 2006 66:10778-85.
  23. Johnson M, Huyn S, Burton JB, Sato M, Wu L. The Differential Biodistribution of Adenoviral Vector In Vivo as Monitored by Bioluminescence Imaging and Quantitative PCR, Human Gene Therapy, in press.